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Biofilms in Wound Healing

Unlike the Biofilm, the Results are Clear to See

About Biofilm

Bye, Bye Biofilms

60% of chronic wounds contain a biofilm1, which could delay healing. IODOSORB’s unique 4 in 1 action has been shown to prevent and disrupt mature biofilms of P. aeruginosa (in-vitro)2,3

Biofilms – A Reason for Delayed Healing

  • Biofilms are dynamic communities of bacteria and fungi living within a protective self-secreted matrix of sugars and proteins.
  • Research shows 60% of chronic wounds contain a biofilm.1
  • The presence of a biofilm has been shown to disrupt normal healing.
  • The result is a non-healing chronic wound stuck in the inflammatory phase of healing.
  • If you’ve treated a chronic wound that failed to progress, despite good wound care, it is possible you have been dealing with a biofilm.

IODOSORB’s unique 4 in 1 action has been shown to prevent and disrupt mature biofilms of P. aerguinosa (in-vitro).2,3

Biofilm Graph

IODOSORB’s Unique 4 in 1 Action

IODOSORB is an effective deslougher4,5,9,10 – which helps cleanse the wound bed and prepare it for effective healing.

IODOSORB has high absorption capacity4,5,6,7,10,11 – which assists with debridement by absorbing excess slough and debris.10,12

IODOSORB provides sustained release of iodine12,13 which has broad spectrum antimicrobial activity (in-vitro)6,10-12,14,15 to help reduce the microbial burden – helping remove the barriers to healing.

  • Local slow release of iodine.4,12
  • Effective against a broad range of bacteria, including MRSA (in-vitro).6,10-12,14,15
  • Changes color to indicate when change is required.13

IODOSORB has been shown to disrupt and substantially eradicate mature biofilms of P. aeruginosa (in-vitro).2,3



1 James, Garth A et al., Biofilms in chronic wounds, Wound Repair and Regeneration (2007).

2 Smith & Nephew Research Centre Work Report #WRP-TSG015-07-003.

3 Phillips, P. L. et al., Effects of Antimicrobial Agents on an (in-vitro) Biofilm Model of Skin Wounds. ADVANCES IN WOUND CARE (2010) 1: 299-304.

4 Sundberg J and Meller R. A retrospective review of the use of cadexomer iodine in the treatment of chronic wounds. Wounds (1997), 9(3): p 68-86.

5 Ormiston MC et al., A randomised comparison of cadexomer iodine and a standard treatment in out-patients with chronic leg ulcers. In Cadexomer Iodine JA Fox, H Fischer eds. (1983) 63-69.

6 Lindsay G et al., A study in general practice of the efficacy of cadexomer iodine in venous leg ulcers treated on alternate days. Acta Therapeutica (1986) 12, p141-148

7 Drosou A, Falabella A, Kirsner MD. Antiseptics on Wounds: An area of controversy. Wounds (May 2003), Vol 15 no 5, p149-166.

8 Phillips PL, Yang QP, Sampson EM, Schultz GS, Unpublished data.

9 Hansson C. The effects of cadexomer iodine paste in the treatment of venous leg ulcers compared with hydrocolloid dressing and paraffin gauze dressing. Int J Dermatology (1998) 37: p390-396.

10 Troeng T et al., In Cadexomer iodine. Fox JA, Fischer H (eds) (1983) p43-50.

11 Johnson A. A combative healer with no ill effect. IODOSORB in the treatment of infected wounds. Professional Nurse (Oct 1991) p60-64.

12 Skog E et al., A randomised trial comparing cadexomer iodine and standard treatment in the outpatient management of chronic venous ulcers. Br J Dermatology (1983) 109, p77-83.

13 Drolshagen C and Schaffer D. Use of absorbent antimicrobial and viscous hydrogel to manage ulcers secondary to peripheral vascular disease. Poster presented at the (1999) Symposium on Advanced Wound Care, Anaheim.

14 Salman H and Leakey A. A report to Smith & Nephew Medical Ltd. The (in-vitro) activity of silver Sulphadiazine and cadexomer iodine against recent clinical isolates of methicillin-resistant Staphylococcus aureus, methicillin-resistant coagulase-negative staphylococci and Pseudomonas aeruginosa. Report number 194-03-01 (March 2001).

15 Mertz PM et al., Can Antimicrobials be effective without impairing wound healing? The evaluation of a cadexomer iodine ointment. Wounds (1994), 6(6), p184-193.

Further Reading

Further Reading

Smith & Nephew has sponsored a Wounds International webcast entitled

“Understanding Biofilm-Based Wound Care; What You Need To Know.”



Bye, Bye Biofilms (PDF -  359kb)
for US Healthcare Professionals 

Bye, Bye Biofilms (PDF - 2.06Mb)  
for Rest of the World Healthcare Professionals